Strategic Research Award - Category I and Category II

ISSUE DATE: January 26, 2018
LETTER OF INTENT DUE DATE: February 20, 2018 by 11:59pm Central time
FULL APPLICATION DUE DATE: June 22, 2018 by 11:59 pm Central time
PERIOD OF AWARD: Project Timeline:
Category I:  1-3 years
Category II:  1-2 years
AMOUNT OF AWARD: Category I:  Up to $250,000 total per award
Category II:  Up to $100,000

The American Sleep Medicine Foundation (ASMF) is accepting letters of intent for the Strategic Research Award (SRA) - Category I and Category II for 2018. Applicants must submit a letter of intent (LOI) no later than 11:59 p.m. Central time on Feb. 20, 2018.


The goals of the SRA programs are to foster health services and patient-oriented research in sleep medicine, to improve patient outcomes and demonstrate value. This is a focused request for applications (RFA) in specific topic areas that will advance the field of sleep medicine. The topics for this RFA are listed below. Studies of high-impact areas of sleep research that do not align with topic specific areas will also be considered. Only applications that fit into one or more of these topic areas will be considered.

  • The SRA Category I is for those applicants seeking funding for projects up to $250,000.
  • The SRA Category II is for those seeking funding for projects up to $100,000.

The ASMF will consider applications that address one of the following research domains:
  1. Patient relevant clinical outcomes in patients with sleep apnea and high positive airway pressure (PAP) adherence: Studies evaluating the potential benefits of PAP therapy related to cardiovascular and cerebrovascular outcomes, mood disorders and mood-related symptoms and quality of life outcomes in patients who have high levels of PAP use. Studies must analyze outcome data based on patients who have high adherence.
  2. Telemedicine for treating and managing patients with sleep disorders who have challenges accessing care (e.g., patients in rural areas): Telemedicine is a promising method for improving access to specialty care for patients with sleep disorders who might otherwise lack access to this care. Studies of telemedicine for the diagnosis and management of patients with sleep apnea, studies evaluating systems of care that incorporate telemedicine, and studies focused on patient-centered outcomes will be considered.
  3. Narcolepsy and other disorders of hypersomnia: Studies are needed to:
    1. Evaluate the efficacy of central nervous system stimulants (e.g., methylphenidate and amphetamine-based stimulants such as dextroamphetamine) in the treatment of narcolepsy and other disorders of hypersomnia in adults and pediatrics. There is specific need for evaluating different forms of these stimulants (e.g., long-acting, extended-release, sustained-release).
    2. Develop and validate a patient reported outcomes tool for pediatric and/or adult patients with CNS hypersomnia conditions that can be used to measure response to treatment.
    3. Develop and test non-pharmacologic interventions for CNS hypersomnias that are delivered alone or coupled with pharmacologic therapy. Examples include: scheduled naps, improved sleep hygiene, rigid sleep scheduling and regular physical exercise.
  4. Adherence to PAP therapy: Studies are needed to enhance both PAP acceptability and PAP adherence. Specific gaps in the literature include:
    1. Studies to evaluate models of PAP initiation that improve acceptability of PAP in newly-diagnosed patients.
    2. Studies to evaluate strategies to increase PAP use in patients already diagnosed and non-adherent.
    3. Evaluation of methods to improve long-term PAP use, specifically, implementation trials of educational, behavioral and other strategies to improve long-term PAP adherence.
    4. Studies to evaluate the impact of changes in PAP modality on adherence.
    5. Studies to evaluate the use of remote monitoring technologies to improve PAP adherence.
    6. Studies targeting patient populations at high risk for non-adherence, for example, based on socioeconomic or health literacy factors.
  5. High-impact sleep research: In addition to the above topics, the ASMF will consider select applications that address novel, innovative or “disruptive” areas of investigation. This may include innovative studies in any area of sleep medicine that would impact patient care and patient outcomes for individuals with sleep disorders. Studies that fit into one of the above categories should NOT be listed under this category.


  • The applicant must be a member of the AASM in good standing.
  • The applicant must possess a masters level degree or higher.
  • The applicant must have access to the necessary resources (including the proposed patient population), facilities and other resources needed to perform the proposed work.
  • The applicant may not already have funding for the work proposed.
  • Payment of award funds must be accepted by the institution in US dollars.

Applicants who are the Principal Investigator on a currently-funded ASMF independent investigator award greater than $20,000 are not eligible to apply. Applicants who have received career development funding from the ASMF are eligible and encouraged to apply. Individuals who are funded by an active ASMF award, but are not the Principal Investigator are also eligible to apply. In all cases, the applicant must clearly demonstrate the lack of overlap between the funded ASMF project and the proposed work and demonstrate that the individual's budgeted and actual percent time/effort involved in the two awards are appropriate and non-overlapping. Potential applicants are encouraged to contact the ASMF to discuss questions or concerns regarding eligibility in advance of submitting an application.

Payment and Reporting Structure

The payment and reporting structure for this award is outlined in the charts below:

Category I Payment Schedule:

Payment #1 – At execution of contract 50%
Payment #2 - At project midpoint and approval of Progress Report 40%
Payment #3 - Upon receipt and approval of Final Report 10%
Reporting – Progress Reports Every six months
Reporting – Final Report  Within 90 days of completion

Category II Payment Schedule:

Payment – Execution of contract 90%
Payment – Upon receipt and approval of Final Report 10%
Reporting – Progress Reports Every six months
Reporting – Final Report Within 90 days of completion

If unique circumstances are explained in the budget justification of the applicant’s proposal, the Board of Directors will consider requests for an alternate payment schedule, with a maximum variance of 10%. Re-allocation of funds <10% do not require approval.

Duration of Award

The award may last up to three years. The project plan and budget must clearly state the expected duration of the proposed project.

Award Review Criteria and Process

An award review committee appointed by the ASMF Executive Committee will evaluate and score all submitted proposals. Factors that will be taken into consideration include the applicant’s experience, availability of resources necessary to complete the study, feasibility and scientific merit of the research plan, environment, responsiveness to current RFA, appropriateness of the proposed research to the ASMF mission, and the anticipated relationship between the funds provided and expected outcomes. Only materials included within the application will be used in the evaluation of applications. The ASMF Board of Directors will make the final determination regarding funding of awards.

Deliverables and Expected Outcomes

Applicants are expected to address the specific aims as described in the application. Major modification of the proposed aims requires ASMF Board approval. The expected results and deliverables should be clearly stated in the application. The applicant must submit progress reports describing project activities and results as described above during the project period. Failure to meet the deliverables or submit progress reports may result in termination of project funding.

Outcomes evaluation is an essential component of this award. All proposals must identify the goals and appropriate outcome measures of the research. The outcomes should align with the goals and objectives stated in the applicant’s proposal for this award. The ASMF intends that the research sponsored under this award will lead to the publication of original research in peer -reviewed journals.

Letter of Intent

A letter of intent (LOI) is required. The LOI will be used to evaluate the responsiveness of the proposed research to the RFA. LOIs that do not include all of the required elements will be rejected. LOIs that describe projects which are not responsive to the topics listed within this RFA will be rejected. The LOI will assist the ASMF with ensuring that appropriate expertise is represented on the award review panel. The link to submit an LOI is provided below.

Criteria for LOI Review

The following criteria will be considered in determining whether the applicant will be invited to submit a full application for consideration:
  1. Topical responsiveness (applications that do not respond to one or more of the RFA topic areas listed above will be rejected)
  2. Potential impact/significance and innovation
  3. Feasibility of the planned research within the SRA-1 mechanism
  4. Overall quality of the methods and analytic plan
  5. Appropriateness of the investigators, consultants and other research partners to conduct the proposed work
Please note that the information submitted in the LOI (e.g., category, key personnel, domain) is final and those invited to submit a full application will be bound by the content of their approved LOI unless a modification was specifically requested or approved by the ASMF.

The LOI should be submitted no later than 11:59pm Central time on Feb. 20, 2018. Investigators will be notified of the outcome of the LOI review no later than April 17, 2018.

Online LOI Submission

To submit an LOI to the ASMF, you must use the online application management system.



Full proposals will be accepted only after review and approval of a Letter of Intent as described above. Individuals invited to submit a full proposal will be provided with the link to the online submission system.

Questions about the Strategic Research Award can be submitted to ASMF Assistant Laura Bentley at