Project Title: Portable Monitoring in the Diagnosis and Management of OSA
Principal Investigator: Carol L. Rosen, MD
Co-Investigator: Susan Redline, MD, MPH
Status: Ongoing
Update: The grant for this large-scale, multi-center, randomized, head-to-head study is the largest that the ASMF has awarded. The initial enrollment and study of more than 350 patients is scheduled to take place from July 2007 to June 2008. The final study report is scheduled to be completed by March 2009.

Project Title: Restoration of Sleep in Heart Failure Patients
Principal Investigator: Frank A.J.L. Scheer, PhD
Co-Investigator: Steven A. Shea, PhD
Status: Ongoing
Update: Through the ASMF grant, this study aims to determine whether or not nighttime melatonin supplementation can improve total sleep time and the quality of life in patients with heart failure treated with β-blockers.

Project Title: Sleep Homeostasis in Primary Insomnia Following Behavioral Treatment
Principal Investigator: Wilfred R. Pigeon, PhD
Status: Ongoing
Update: The proposed study is intended to be a preliminary evaluation of the MSD/MSLT protocol and its relevance for treatment outcome and our understanding of the pathophysiology of chronic insomnia.

Project Title: Effect of Sleep Medicine Specialist Expertise and American Academy of Sleep Medicine Accreditation on the Treatment of Obstructive Sleep Apnea
Principal Investigator: Sairam Parthasarathy, MD
Status: Ongoing
Update: Results of a Web-based questionnaire suggest that patients cared for in accredited centers and by certified physicians were less likely to discontinue positive airway pressure therapy. More than 800 patients are being recruited for the next phase of the study.
Publication: Parthasarathy S, Haynes PL, Budhiraja R, Habib MP, Quan SF. A national survey of the effect of sleep medicine specialists and American Academy of Sleep Medicine accreditation on management of obstructive sleep apnea. J Clin Sleep Med 2006;2(2):133-142.

Project Title: Neural Correlates of Adaptation to Sleep Deprivation in Obstructive Sleep Apnea – A Pilot Study
Principal Investigator: Kimberly N. Hutchison, MD
Status: Ongoing
Update: This study aims to use functional magnetic resonance imaging (fMRI) to examine the effects of 24 hours of sleep deprivation on neural networks during executive function (Stroop) and vigilance (auditory odd-ball) tasks in normal controls. We will analyze these activation patterns in relation to task performance and to the degree of sleepiness as measured by the Multiple Sleep Latency Test (MSLT).

Project Title: Neural Activity and Sleep Dependent Plasticity
Principal Investigator: Sushil K. Jha, PhD
Status: Ongoing
Update: The aims of this study are to determine changes in single neuron activity in primary visual cortex across sleep-wakefulness, before, during and after MD that induces rapid synaptic remodeling; to understand the relative roles of neuronal activity during REM sleep and NREM sleep on sleep-dependent plasticity; and to comprehend if specific firing pattern that instruct the formation of particular circuitry involved such OD plasticity (instructive role) or certain level of firing rate determine the changes (permissive role).

Project Title: Neurophysical Investigation of Pain Induced Arousal
Principal Investigator: Kevin M. Hellman, PhD
Status: Ongoing
Update: This study intends to examine the hypothesis that the sensory suppression that accompanies NREM sleep is mediated by neurons in the medullary raphe Magnus (RM), and area that is necessary for opioid analgesia and critical to the development of neuropathic pain.

Project Title: Daytime Sleepiness and Parkinsonism in Patients with Mild Alzheimer’s disease
Principal Investigator: Margaret Park, MD
Status: Ongoing
Update: The proposed study is intended to be a preliminary evaluation of pathological sleepiness in patients with Alzheimer’s disease. Analyses will focus on the association between Parkinsonism and MSLT results in patients with mild Alzheimer’s disease. The value in this line of investigation is in its potential to expand clinical parameters in assessing Alzheimer’s disease prognosis as well as expanding knowledge with regards to possible pathophysiologic mechanisms underlying sleepiness in Alzheimer’s disease patients.

Project Title: Evaluation of Cognitive Behavioral Social Rhythm Therapy for Sleep and Scheduling Disturbances in Patients with Comorbid Postraumatic Stress Disorder and Depression
Principal Investigator: Patricia L. Haynes, PhD
Status: Ongoing
Update: The goal of this study is to test the efficacy of Cognitive Behavioral Social Rhythm therapy, a treatment that targets both sleep complaints and emotional dysregulation, to help patients with sleep disturbances comorbid with posttraumatic stress disorder and major depressive disorder.